• News
  • Training

Welcome

Forgot password?

Not a member? Join today

Logo
  • Home
  • About Us
  • Research
        • Scientific Directions
        • Today, the Eliava Institute of Bacteriophages, Microbiology and Virology (IBMV) continues its rich tradition of work in applied microbiology and bacteriophage research.

        • Bacterial Strain and Phage Collection
        • George Eliava Institute of Bacteriophages, Microbiology and Virology has the most extensive and valuable bacterial strain and bacteriophage collection in the world.

        • Scientific Laboratories
          • Laboratory of General Microbiology
          • Laboratory of Applied Microbiology
          • Laboratory of Microbial Ecology
          • Laboratory of Molecular Biology
          • Laboratory of Virology and Immunology
          • Bacterial Strains and Phage Collection
          • R&D Department
  • Eliava Foundation
        • Eliava Phage Therapy Center
        • Eliava Biopreperations
        • Eliava Analytical-Diagnostic Center
        • Eliava Pharmacy
        • Eliava Bacteriological Media Production
        • Eliava Technology Commercialization Office
  • Contact
  • ქართულიქართული

Laboratory of General Microbiology

The main research interest and scientific activity of the laboratory is the isolation of bacteriophages against various pathogenic bacterial strains and study phage-biology and genetics, as well as the elaboration of different medicinal forms of phage preparations and development of technology for phage production.

Laboratory Personnel:

Marina Goderdzishvili, PhD – Head of the Laboratory   Email:   (mgoderdzishvili@pha.ge)
Irina Chkonia, PhD – Leading Scientist   Email:   (irinachkonia@pha.ge)
Ia Kusradze, PhD – Senior Scientist   Email:   (iakusradze@pha.ge)
Natia Karumidze, PhD – Senior Scientist   Email:   (natiaqarumidze@pha.ge)
Sophie Rigvava, PhD – Senior Scientist   Email:   (sophierigvava@pha.ge)
Teona Dvalidze – Scientist
Nino Qvatadze – Technician
Darejan Jgenti – Technician

Participation in Scientific Grant Projects:

  • 2019-2023 Ferring Pharmaceuticals: “Developments of Phage-based Products in the field of Reproductive Medicine and Women’s health”
  • 2017-2021, H2020-FETOPEN 767015, “Constructing a Eubiosis Reinstatement Therapy for Asthma” (Co PI: N. Chanishvili).
  • 2016-2017, SRNSF 217874, “The role of XhIA domain containing protein in the development of lysogenic conversion“ (PI: S. Rigvava).
  • 2015-2017, ISTC A-1420, “Targeted elimination of multidrug-resistant (MDR) Salmonella by bacteriophages” (Co PI: N. Chanishvili).

See more

  • 2015-2018, STCU P664, “Isolation and Detailed Characterization of Bacteriophages Lytic to Human Pathogenic Species Intrinsically Resistant to Antibiotics” (PI: M. Tediashvili).
  • 2014-2016, SNSF-SCOPES N 152304, “Bacteriophage therapy for treating urinary tract infections: A randomized placebo – controlled, double-blind trial“ (PI: N. Chanishvili).
  • 2010-2015, 7FP Program: Industry Academia Partnership Pathways (Acronym – ”NanoBacteriophageSERS”), “Design of Novel Portable-Sensors Based on Suspension Arrays Composed of Monoclonal Antibody and Bacteriophage Carrying Magnetically Loaded Nanoparticles and Surface Enriched Raman Spectroscopy (SERS)” (Co-PI: N. Chanishvili).
  • 2012 -2014, STCU P 450, “Screening of anti-virus activity of indol-containing tetracyclic condensed systems for application in veterinary medicine” (PI: M. Tediashvili).
  • 2011-2013, ISTC G1912p, “Development of bacteriophage products as alternative to antibiotics to control bacterial diseases of liverstock animals: Stage I – Selection of the promising candidate bacteriophages against Salmonella typhimurium, E.coli, Streptococcus suis and Cl. perfringens” (PI: N. Chanishvili).
  • 2009-2012, ISTC G1666, “Development of a New Phage Composite Targeted to Prevent and Treat Mixed Infections” (PI: I.Chkonia).
  • 2007-2008, ISTC 1467, “Preparation of a detailed review article/monograph on the practical application of bacteriophages in medicine, veterinary, environmental research based on old documents and publications” (PI: N. Chanishvili).
  • 2006-2009, ISTC G1369, “Microflora of inflammatory process in chronic prostatitis and urogenital tracts in men and phage therapy prospects” (PI: Z. Alavidze).
  • 2005-2008, GEB2 1958 TB 05, “Isolation, distribution and biodiversity of selected Vibrios and their bacteriophages from aquatic environments in Georgia” (PI: M. Tediashvili).
  • 2004-2007, STCU-Gr-115, “Creation and Study of Antimicrobial-Antifungal Composite Using Biodegradable Polymer as a Matrix” (PI: M. Goderdzishvili).
  • 2001-2003, ISTC G446, “Bacteriophages Containing Drug Sustained/Controlled Release Type Polymeric Composites – New Effective Preparations for the Treatment of Infected Wounds and Cavites” (Co-PI: M. Goderdzishvili).

Individual projects:

Sophie Rigvava – 2018-2020- SRNSF Research Grants for young scientists YS-18-413- “Isolation and study of antibacterial effectiveness of phages against Group B Streptococcus”

Natia Karumidze – 2015-2016 – Swiss Government Excellence Scholarship, University of Bern, Switzerland.

Natia Karumidze – 2014-2015 – Grant project “Endolysins as new class of antibacterials.” Eliava Institute and Harvard Medical school, Boston, USA.

See more

Ia Kusradze – 2014 – Shota Rustaveli National Science Foundation –  Individual Grant Project- Phage Engineering with Bacterial Biofilm Dispersing Gene- MIT, Synthetic Biology Centre, USA.

Teona Dvalidze – 2013-2014 – Shota Rustaveli National Science Foundation individual grant: “Study of the interaction of antibiotics, phages purulent-inflammatory infections” University of Leicester.  Department of Infection, Immunity and Inflammation Laboratory, UK.

Sophie Rigvava – 2013 – Identification and characterization Enterococcus Phage Endolysins. Harvard Medical School, Boston, USA.

Sophie Rigvava – 2012 – Presidential grant for young scientists 2012 – Efficacy of Phage therapy against Sepsis caused by Staphylococcus aureus and Enterococcus faecalis

Teona Dvalidze – 2012 – Shota Rustaveli National Science Foundation individual grant:  The study of bacteriophages (Klebsiella pneumoniae and Acinetobacter baumannii) activity in the Galleria mellonella infection model” University of Leicester. Department of Infection, Immunity and Inflammation Laboratory, UK.

Ia kusradze – 2012 – Shota Rustaveli National Science Foundation –  Individual Grant Project-Bioinformatics analyzing of phage genomes-Bioinformatics Centre, Institute for Chemical Research, Kyoto University, Japan.

Natia Karumidze – 2012 – Shota Rustaveli National Science Foundation, Individual Grant Project-“Biofilm Formation and their Inhibition with Bacteriophages” Lab of Physical Chemistry of living surfaces, University of Pierre and Marie Curie, Paris, France

Ia kusradze – 2010 – GNSF-Individual Grant Project –Study of Genetics of  Acinetobacter baumannii phages-Molecular Biology; Faculté de Médecine et de Pharmacie, Université de la Méditerranée Aix-Marseille, France.

Natia Karumidze – 2010- Shota Rustaveli National Science Foundation, Individual Grant Project “Isolation and study of freshly isolated clones of Klebsiella pneumoniae Bacteriophages” – University of Leicester, UK.

Sophie Rigvava – 2009-2010- Individual Grant Project, Georgian National Science Scholars Program GRDF/GNSF08/532 No. 0308 – Characterization of Enterococcus faecium Specific Bacteriophages-Bacteriophage Evolutionary Ecology Research, Queens College, City University of NY, USA.

Natia Karumidze – 2009-2010- Individual grant project, Georgian national Science Scholars Program GRDF/GNSF08/532 No. 0408 “Characterization of freshly isolated clones of bacteriophages against P.aeruginosa and Klebsiella for involving them into natural antimicrobial-antifungal biocomposite”.  The research was done in health Science Center at San Antonio, Texas, USA.

List of Selected Publications:

  • Lorenz Leitner, Aleksandre Ujmajuridze, Nina Chanishvili, Marina Goderdzishvili, , Ulrich Mehnert, Archil Chkhotua, Wilbert Sybesma, Thomas M. Kessler “Adapted bacteriophages for treating urinary tract infections” April 2019 The Journal of Urology 201(Supplement 4)DOI: 10.1097/01.JU.0000556530.61448.e3
  • Rigvava1, 2, Sh. Kharebava3, T Giorgobiani2, 3, T.Dvalidze1, M.Goderdzishvili1 “Identification and antibiotic susceptibility patterns of Streptococcus agalactiae“ GMN. 12.2019
  • S. Rigvava, I. Kusradze, N. Karumidze, T. Dvalidze, M. Katsitadze, S. Barbakadze, D. Bolkvadze, M. Goderdzishvili – “New Temperate Enterococcus phage vB_GEC_EFS_2 with potential of lysogenic conversion”, GMN Georgian Med News, 2018, (274):158-164.
  • L. Leitner, W. Sybesma, N. Chanishvili, M. Goderdzishvili, T. M. Kessler – “Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: A randomized, placebo-controlled, double-blind clinical trial”, BMC Urology, 2017, 17(1):90.
  • F. Nogueira, N. Karumidze, I. Kusradze, M. Goderdzishvili, I. C. Gouveia – “Immobilization of bacteriophage in wound-dressing nanostructure”, Nanomedicine: nanotechnology, biology, and medicine, 2017, V13.(8), pp. 2475-2484.

See more

  • I. Kusradze, N. Karumidze, S. Rigvava, T. Dvalidze, M. Katsitadze, I. Amiranashvili, M. Goderdzishvili – ”Characterization and Testing the Efficiency of Acinetobacter baumannii Phage vB-GEC_Ab-M-G7 as an Antibacterial Agent”, Front Microbiol, 2016, 4;7:1590.
  • A. Uimajuridze, G. Jvania, N. Chanishvili, M. Goderdzishvili, W. Sybesma, L. Managadze, A. Chkhotua, T. Kessler – “265 Phage therapy for the treatment for urinary tract infection: Results of in-vitro screenings and in-vivo application using commercially available bacteriophage cocktails”, European Urology Supplements, 2016, Volume 15, Issue 3, Page e265.
  • H. Zschach, K. Joensen, B. Lindhard, O. Lund, M. Goderdzishvili, I. Chkonia, G. Jgenti, N. Kvatadze, Z. Alavidze, E. Kutter, H. Hasman, M. Larsen – “What Can We Learn from a Metagenomic Analysis of a Georgian Bacteriophage Cocktail?”, Viruses, 2015, 7(12), 6570-6589.
  • J.P. Pirnay, B. Blasdel, L. Bretaudeau, A. Buckling, N. Chanishvili, M. Goderdzishvili, F. Pouilot, G. Resch, C. Rohde, J. Scheres, M. Skurnik, M. Vaneechoutte, L. Van Parys, G. Verbeken, M. Zizi, G. Van den Eed – “Quality and Safety Requirements for Sustainable Phage Therapy Products”, Pharmaceutical research, 2015, 32(7):2173-9.
  • J. Sahota, C. Smith, P. Radhakrishnan, C. Winstanley, M. Goderdzishvili, N. Chanishvili, A. Kadioglu, C. O’Callaghan, M. Clokie – “Bacteriophage Delivery by Nebulization and Efficacy against Phenotypically Diverse Pseudomonas aeruginosa from Cystic Fibrosis Patients”, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2015, 28(5):353-60.
  • K. Elizabeth, J. Borysowski, R. Międzybrodzki, A. Górski, B. Weber-Dąbrowska, M. Kutateladze, Z. Alavidze, M. Goderdzishvili, R. Adamia – “Clinical Phage Therapy”, Chapter 11, In the book: Phage Therapy: Current Research and Applications, 2014, Editor: Jan Borysowski, Ryszard Międzybrodzki and Andrzej Górski, Caister Academic Press, 2014.
  • N. Karumidze, I. Kusradze, S. Rigvava, M. Goderdzishvili, K. Rajakumar, Z. Alavidze – “Isolation and Characterisation of Lytic Bacteriophages of Klebsiella pneumoniae and Klebsiella oxytoca”, Current Microbiology, 2013, v. 66, Issue 3, pp. 251-258.
  • S. Rigvava, I. Tchkonia, M. Goderdzishvili, D. Jgenti, T. Dvalidze, J. Carpino – “Comparative Analyses of Biological and Physical Properties of Enterococcus faecalis Bacteriophage vB_EfS_3 and Streptococcus mitis Bacteriophage vB_SmitisM_2”, Canadian Journal of Microbiology, 2013, v. 59, issue 1, pp 18-21.
  • N. Karumidze, J. Thomas, N. Kvatadze, M. Goderdzishvili, K. Hakala, S. Weintraub, Z. Alavidze, S. Hardies – “Characterization of lytic Pseudomonas aeruginosa bacteriophages via biological properties and genomic sequences”, Applied Microbiology and Biotechnology, 2012, v. 94, Issue 6, pp 1609-1617.
  • I. Kusradze, S. Diene, M. Goderdzishvili, J.M. Rolainb – “Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia”, International Journal of Antimicrobial Agents, 2011, v. 38, Issue 2, pp.164–168.
© Copyright Eliava Institute 2020. All rights reserved.