Activity of the laboratory includes scientific research for human health and veterinary. The lab is working on study a humoral immunity status and protective immunoglobulins (IgA,IgG,IgM) for viral, bacterial and mixed infection. Correlation analysis of some representatives of the family of Herpes virus with other agents of non-viral ethology is one of the topics of the laboratory research.
Immune reactions of organisms in the process of therapeutic bacteriophage application, in particular, determination of non-specific and specific indicators of immunity are studied.
The groups is working on development of therapeutic-preventive immune-biological preparations (vaccines, sera).
Laboratory Personnel:
Sergo Rigvava, PhD – Head of the Laboratory Email: (s.rigvava@pha.ge)
Nana Topuria, PhD – Leading scientist Email: (n.topuria@pha.ge)
Dali Gogiashvili, PhD – Senior scientist Email: (d.gogiashvili@pha.ge)
Helen Akhalaia, PhD – Junior scientist
Nana Sabauri – Senior lab technician
Lia Gubeladze – Lab technician
Participation in Scientific Grant Projects:
2013-2016, FP7 “Anthrax environmental decontamination network” (PI: M. Kutateladze).
2013-2015, DTRA/CRDF, “Characterization of the mechanisms of adaptive phage-host coevolution using next generation sequencing and phenotypic profiling” (PI: M. Kutateladze)
2011-2013, STCU and French Defence Agency P486 “Application of bacteriophages against highly pathogenesis bacteria in model studies” (PI: M Tediashvili).
2009-2012, ID: GG-18, “Ecology, genetic clustering and virulence of major bacterial and viral pathogens in the Republic of Georgia” (PI: M. Kutateladze).2007-2009, ISTC G-416 “Elaboration of an improved technology for obtaining anti-Anthrax polyclonal immunoglobulin” (PI: D. Gogiashvili).
2008, “Tbilisi Water” Ltd, Indication of viruses and bacteria causing intestinal infections in Tbilisi water supply system and epidemiological analysis (PI: N. Topuria).
2006-2007, CRDF GB2-2497-TB-03 “Selection of bacteriophages related to B.anthracis: Elaboration of the Phage Amplification Assay for rapid detection of bacteria in contaminated materials” (PI: S. Rigvava).
2005-2006, ISTC G416.2 “Elaboration of an improved technology for obtaining anti-Anthrax polyclonal immunoglobulin” (PI: D. Gogiashvili).
2002-2004, INTAS 0725, “An epidemiological study of outbreaks of B. anthracis in Georgia” (PI: S. Rigvava).
GEB 25049 TB-05, Development and testing effectiveness of a phage preparation for the treatment of canine otitis caused by Pseudomonas aeruginosa (PI. N.Tophuria).
List of Selected Publications:
Gubeladze L,Gogiashvili D, Rigvava S, Natidze M, et al. The Isolation of Bacteriophages Lytic to B.anthracis from Environmental sources in Georgia, 3rd report: B.anthracis-specific phages isolated in 2012 in Georgia. Intern. J.of Current Research, 2018, vol.4, Issue 5, p.1-4. DOI:10:29941.2018.
N. Topuria-Nakaidze, I. Giorgadze, N. Odishelodze, N. Sabauri, E. Akhalaia L. Tkemaladze, T. Katukia – “Correlation analyses between Herpes Simplex Virus and other pathogens causing infections in females of reproductive age”, Experimental & Clinical Medicine, 2017, #4, p. 61-65.
S. Rigvava, L. Gubeladze, N. Vardzelashvili, D. Gogiashvili, M. Natidze – “Serological express diagnostics of bacterial sepsis”, Ninth International Symposium “New Steps in Critical Care Medicine”, Georgian Critical Care Medicine, #37, 18. http://CCCMJ.ge.
L. Gubeladze, D. Gogiashvili, S. Rigvava, M. Natidze, T. Kokashvili, G. Tsertsvadze, M. Tediashvili – “Comparative biological characterization of phages specific to B.anthracis isolated from environmental sources in Georgia”, Communication 1. B. anthracis –specific phages isolated in Georgia in 2008-2009, Journal of Experimental and Clinical Medicine, 2017, #3, 123–129.
L. Gubeladze, D. Gogiashvili, S. Rigvava, M. Natidze, G. Kamkamidze, G. Tsertsvadze, M. Tediashvili – “Comparative biological characterization of phages specific to B.anthracis isolated from environmental sources in Georgia”, 2ndreport. B anthracis specific phages isolated in Georgia in 2010-2011, The Black Sea, Scientific Journal of Academic Research, 2017, volume 37. p. 68-70.
Z. Kheladze, S. Rigvava, M. Danielov, S. Makharashvili, N. Chubinidze – “Immunosorbtion – new methods for treatments of Sepsis”, New Steps in Critical Care Medicine 2017, Georgian Critical Care Medicine, #37, 23. http://CCCMJ
M. Natidze, S. Rigvava – “Antibiotic sensitivity of Anthrax vaccine strains and some species belonging to the genus Bacillus”, Experimental & Clinical Medicine, 2017, #4, pp. 81–84.
PATENTS:
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. FERSISI bacteriophage. Trade mark. National Intellectual Property Center of Georgia “Saqpatenti”. 94348/35, 2017.
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. SES bacteriophage. Trade mark. National Intellectual Property Center of Georgia “Saqpatenti”. 94350/3, 2017.
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. FERSISI bacteriophage. Trade mark. National Intellectual Property Center of Georgia “Saqpatenti”. 94349/3, 2017.
Giorgadze, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage suppositories. National Intellectual Property Center of Georgia “Saqpatenti”. 14532/2, AU 201714532, 2017.
Giorgadze, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage ointment. National Intellectual Property Center of Georgia “Saqpatenti”. 14531/2, AU 201714531, 2017.
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage “FERSISI”. National Intellectual Property Center of Georgia “Saqpatenti”. 14534/2, AU 201714534, 2017.
Georgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage “ENKO”. National Intellectual Property Center of Georgia “Saqpatenti”. 14533/2, AU 201714533, 2017.
Georgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage “SES”. National Intellectual Property Center of Georgia “Saqpatenti”. 14535/2, AU 201714535, 2017.