Activity of the Laboratory includes scientific researches in medicine and veterinary, in particular, study of theoretical and applied issues.
In the cases of viral, bacterial and mixed infection a humoral immunity status is estimated and classes of protective immunoglobulins (IgA,IgG,IgM) are studied.
Correlation analizis of some representatives of the family of Herpes virus with other agents of non-viral etiology are performed.
Immune reactions at the organisms are studied in the process of therapeutic bacteriophage application, in particular, determination of non-specific and specific indicators of immunity.
Therapeutic-preventive immunobiological preparations (vaccines, sera) are developed.
The team performs detection of a number of viruses. It has been working actively on analyzing results of the infections caused by herpes simplex virus type 1 and type 2 for last ten years and also, team elaborates results for the possible association of this virus with other viruses as well as bacteria and primitive organisms.
Laboratory Personnel:
Sergo Rigvava, PhD – Head of the Laboratory Email: (s.rigvava@pha.ge)
Nana Topuria, PhD – Leading scientist Email: (n.topuria@pha.ge)
Dali Gogiashvili, PhD – Senior scientist Email: (d.gogiashvili@pha.ge)
Helen Akhalaia, PhD – Junior scientist
Nana Sabauri – Senior lab technician
Lia Gubeladze – Lab technician
Participation in Scientific Grant Projects:
2018, “Elaboration of an improved technology of obtaining heterogeneous anti-Anthrax immunoglobulin“.
2017, “Study of anti-phage antibodies in the patients treated with Staphylococcal bacteriophages”.
2013-2016, FP7 “Anthrax environmental decontamination network”.
2013-2015, DTRA/CRDF, “Characterization of the mechanisms of adaptive phage-host coevolution using next generation sequencing and phenotypic profiling”.
2011-2013, STCU and French Defense Agency P486 “Application of bacteriophages against highly pathogenesis bacteria in model studies” (PI: M Tediashvili).
2009-2012, ID:GG-18, “Ecology, genetic clustering and virulence of major bacterial and viral pathogens in the Republic of Georgia” (PI: M. Kutateladze).
2007-2009, ISTC G-416,3 “Elaboration of an improved technology for obtaining anti-Anthrax polyclonal immunoglobulin” (PI: D. Gogiashvili).
2008, Ltd “Tbilisi Water”, Indication of viruses and bacteria causing intestinal infections in Tbilisi water supply system and epidemiological analysis (PI: N. Topuria).
2006-2007, CRDF GB2-2497-TB-03 “Selection of bacteriophages related to Bac.anthracis: Elaboration of the Phage Amplification Assay for rapid detection of bacteria in contaminated materials” (PI: S. Rigvava).
2005-2006, ISTC G416.2 “Elaboration of an improved technology for obtaining anti-Anthrax polyclonal immunoglobulin” (PI: D. Gogiashvili).
2003-2005, Georgian Academy of Science, Development of various therapeutic forms based on new phages.
2002-2004, INTAS 0725, “An epidemiological study of outbreaks of Bac. anthracis in Georgia” (PI: S. Rigvava).
2002, ISTC G416.1, “Elaboration of an improved technology for obtaining anti-Anthrax polyclonal immunoglobulin” (PI: D. Gogiashvili).
2000-2002, Georgian Academy of Science, Study of effectiveness of new therapeutic-preventive bacteriophages and other combined immunobiological preparations for medical and veterinary practice.
GB 22492 TB -03, Therapeutic-prophylactic phage preparations against bacterial complications induced by proteus and Pseudomonas in extreme conditions.
GEB 25049 TB-05, Development and testing effectiveness of a phage preparation for the treatment of canine otitis caused by Pseudomonas aeruginosa.
GG-18 Ecology, genetic clustering and virulence of major bacterial and viral pathogens in the Republic of Georgia.
List of Selected Publications:
N. Topuria-Nakaidze, I. Giorgadze, N. Odishelodze, N. Sabauri, E. Akhalaia L. Tkemaladze, T. Katukia – “Correlation analyses between Herpes Simplex Virus and other pathogens causing infections in females of reproductive age”, Experimental & Clinical Medicine, 2017, #4, p. 61-65.
N. Topuria-Nakaidze, I. Giorgadze, N. Odishelodze, N. Sabauri, E. Akhalaia, L. Tkemaladze, T. Katukia – “The study of the Correlation between herpes simplex virus and bacterial vaginosos”, Centential celebration of Bacteriophage research -100 Anniversary, Poster Presentations, Tbilisi, Georgia, 2017, 109.
S. Rigvava, L. Gubeladze, N. Vardzelashvili, D. Gogiashvili, M. Natidze – “Serological express diagnostics of bacterial sepsis”, Ninth International Simposium “New Steps in Critical Care Medicine”, Georgian Critical Care Medicine, #37, 18. http://CCCMJ.ge
L. Gubeladze, D. Gogiashvili, S. Rigvava, M. Natidze, T. Kokashvili, G. Tsertsvadze, M. Tediashvili – “Comparative biological characterization of phages specific to B.anthracis isolated from environmental sources in Georgia”, Communication 1. B. anthracis –specific phages isolated in Georgia in 2008-2009, Journal of Experimental and Clinical Medicine, 2017, #3, 123–129.
L. Gubeladze, D. Gogiashvili, S. Rigvava, M. Natidze, G. Kamkamidze, G. Tsertsvadze, M. Tediashvili – “Comparative biological characterization of phages specific to B.anthracis isolated from environmental sources in Georgia”, 2ndreport. B anthracis specific phages isolated in Georgia in 2010-2011, The Black Sea, Scientific Journal of Academic Research, 2017, volume 37. p. 68-70.
Z. Kheladze, S. Rigvava, M. Danielov, S. Makharashvili, N. Chubinidze (Georgia-USA) – “Immunosorbtion – new methods for treatments of Sepsis”, New Steps in Critical Care Medicine 2017, Georgian Critical Care Medicine, #37, 23. http://CCCMJ
M. Natidze, S. Rigvava – “Antibiotic sensitivity of Anthrax vaccine strains and some species belonging to the genus Bacillus”, Experimental & Clinical Medicine, 2017, #4, pp. 81–84.
S. Rigvava – “Serological Express Diagnostics of Bacterial Sepsis”, Report (speech) at the international conference: Ninth International Symposium, New Steps in Critical Care Medicine, Tbilisi, 2017. http://CCCMJ.ge.
M. Natadze, S. Rigvava – “Prions- Causatives of Slow Infections” Text-book, Tbilisi, 2017, p. 67.
Patents:
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. FERSISI bacteriophage. Trade mark. National Intellectual Property Center of Georgia “Saqpatenti”. 94348/35, 2017.
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. SES bacteriophage. Trade mark. National Intellectual Property Center of Georgia “Saqpatenti”. 94350/3, 2017.
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. FERSISI bacteriophage. Trade mark. National Intellectual Property Center of Georgia “Saqpatenti”. 94349/3, 2017.
Giorgadze, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage suppositories. National Intellectual Property Center of Georgia “Saqpatenti”. 14532/2,AU 201714532, 2017.
Giorgadze, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage ointment. National Intellectual Property Center of Georgia “Saqpatenti”. 14531/2,AU 201714531, 2017.
Giorgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage “FERSISI”. National Intellectual Property Center of Georgia “Saqpatenti”. 14534/2,AU 201714534, 2017.
Georgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage “ENKO”. National Intellectual Property Center of Georgia “Saqpatenti”. 14533/2,AU 201714533, 2017.
Georgadze, T. Gabisonia, N. Topuria-Nakaidze, L. Tkemaladze. Technique for preparing bacteriophage “SES”. National Intellectual Property Center of Georgia “Saqpatenti”. 14535/2,AU 201714535, 2017.